The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency
Electrons feed into the mitochondrial electron transport chain (mETC) from NAD- or FAD-dependent enzymes.A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the oxidation capacity of the dedicated coenzyme Q (CoQ) pool and result in the generation of reactive oxygen species.To prevent this, the mETC superstru